Simulated datasets

This is the base case

In this dataset, no only amino acid substitutions at a fixed rate are modeled. This is the base case for any further analysis.

DisturbanceVertabrate-like TreeBacteria-like Tree
Tree 1Tree 2Tree 3Tree 1Tree 2Tree 3
n/aRepl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5

Variation of Gene Duplication and Loss Rate

In addition to amino acid substitutions, for these datasets the gene duplication rate is varied (in percent of affected genes in the present day genomes) and also the loss rate (given as the ratio of loss rate and duplication rate).

DisturbanceVertabrate-like TreeBacteria-like Tree
Dupl [%], Dupl-Loss-RatioTree 1Tree 2Tree 3Tree 1Tree 2Tree 3
10%, 1Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
20%, 1Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
30%, 1Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
40%, 1Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
10%, 3Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
30%, 0.333Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
40%, 0Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5

Variation of Lateral Gene Transfer Rate

On these datasets we model different rates of lateral gene transfers with orthologous replacement.

DisturbanceVertabrate-like TreeBacteria-like Tree
LGTs [%]Tree 1Tree 2Tree 3Tree 1Tree 2Tree 3
10Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
20Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
40Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
60Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
80Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5

Variation of Base-Calling Error Rate

On these datasets we model errors in the sequencing step. We replace a random fraction of positions with other amino acids.

DisturbanceVertabrate-like TreeBacteria-like Tree
Sites [%]Tree 1Tree 2Tree 3Tree 1Tree 2Tree 3
6Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
9Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
12Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
15Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
18Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5

Variation of Insertion/Deletion Rate

For these datasets we varied the insertion/deletion rate during the evolution.

DisturbanceVertabrate-like TreeBacteria-like Tree
InDel-RateTree 1Tree 2Tree 3Tree 1Tree 2Tree 3
0.000125Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
0.00025Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
0.0005Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
0.001Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
0.002Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5
Repl 1
Repl 2
Repl 3
Repl 4
Repl 5