Benchmark Results:






Project # completed tree samplings (of 50k trials) # uploaded orthologs avg RF distance( genetree , speciestree ) avg fraction incorrect trees Raw Data
EggNOG 83412262770.0749 +- 0.00400.1541 +- 0.0077
Ensembl Compara (e56) 96732378940.0845 +- 0.00400.1687 +- 0.0075
Ensembl Compara (e81) 109742693120.0871 +- 0.00370.1810 +- 0.0072
Hieranoid 2 100382846480.0585 +- 0.00320.1229 +- 0.0064
InParanoid 119253010140.0547 +- 0.00280.1207 +- 0.0058
InParanoidCore 78082109060.0559 +- 0.00360.1172 +- 0.0071
OMA GETHOGs 84903507220.0562 +- 0.00340.1198 +- 0.0069
OMA GETHOGs 2.0 79027132890.0614 +- 0.00370.1302 +- 0.0074
OMA Groups (RefSet5) 48991761110.0500 +- 0.00440.1017 +- 0.0085
OMA Groups 2.0 63701931440.0508 +- 0.00390.1049 +- 0.0075
OMA Pairs 2.0 90513466870.0577 +- 0.00350.1195 +- 0.0067
OrthoFinder 2.0 (Defaults, with BLAST) 120753377430.0749 +- 0.00330.1598 +- 0.0065
OrthoFinder 2.0 (Defaults, with DIAMOND) 115403122880.0725 +- 0.00330.1538 +- 0.0066
OrthoFinder 2.0 (MSA, with BLAST) 125353515430.0838 +- 0.00340.1773 +- 0.0067
PANTHER 8.0 (LDO only) 66662031900.0498 +- 0.00360.1080 +- 0.0075
PANTHER 8.0 (all) 136534091860.0739 +- 0.00300.1637 +- 0.0062
RBH / BBH 92342299650.0672 +- 0.00360.1444 +- 0.0072
RSD 0.8 1e-5 Deluca 88802196460.0699 +- 0.00370.1471 +- 0.0074
SonicParanoid (default) [50% max-len-diff] 112653155290.0628 +- 0.00310.1356 +- 0.0063
SonicParanoid (fast) [50% max-len-diff] 107843043280.0578 +- 0.00310.1249 +- 0.0062
SonicParanoid CORE (default) [50% max-len-diff] 85112201780.0616 +- 0.00360.1312 +- 0.0072
SonicParanoid CORE (fast) [50% max-len-diff] 81302152470.0609 +- 0.00370.1282 +- 0.0073
metaPhOrs 137023475410.0848 +- 0.00330.1813 +- 0.0065
orthoinspector 1.30 (blast threshold 10-9) 103852688250.0624 +- 0.00330.1329 +- 0.0065
phylomeDB 118663071750.0649 +- 0.00310.1391 +- 0.0062
OMA Pairs (Refset5) 82392723140.0537 +- 0.00340.1140 +- 0.0069



Project # completed tree samplings (of 50k trials) # uploaded orthologs avg RF distance( genetree , speciestree ) avg fraction incorrect trees Raw Data
EggNOG 2062148210.237 +- 0.0130.405 +- 0.021
Ensembl Compara (e56) 1867141520.260 +- 0.0150.436 +- 0.022
Ensembl Compara (e81) 1945143590.251 +- 0.0140.425 +- 0.022
Hieranoid 2 2144152470.228 +- 0.0130.395 +- 0.021
InParanoid 2315164970.241 +- 0.0130.411 +- 0.020
InParanoidCore 1673121230.217 +- 0.0140.380 +- 0.023
OMA GETHOGs 1827136710.227 +- 0.0140.392 +- 0.022
OMA GETHOGs 2.0 1400129540.209 +- 0.0160.363 +- 0.025
OMA Groups (RefSet5) 52966230.194 +- 0.0250.340 +- 0.040
OMA Groups 2.0 94583530.196 +- 0.0180.345 +- 0.030
OMA Pairs 2.0 1524130560.215 +- 0.0150.368 +- 0.024
OrthoFinder 2.0 (Defaults, with BLAST) 2768190910.266 +- 0.0120.445 +- 0.019
OrthoFinder 2.0 (Defaults, with DIAMOND) 2730187540.266 +- 0.0120.448 +- 0.019
OrthoFinder 2.0 (MSA, with BLAST) 2760189290.268 +- 0.0120.449 +- 0.019
PANTHER 8.0 (LDO only) 2034113400.243 +- 0.0140.417 +- 0.021
PANTHER 8.0 (all) 2572173380.284 +- 0.0130.465 +- 0.019
RBH / BBH 2210141350.256 +- 0.0130.433 +- 0.021
RSD 0.8 1e-5 Deluca 1945126730.249 +- 0.0140.424 +- 0.022
SonicParanoid (default) [50% max-len-diff] 2263157690.241 +- 0.0130.410 +- 0.020
SonicParanoid (fast) [50% max-len-diff] 1974146810.229 +- 0.0140.395 +- 0.022
SonicParanoid CORE (default) [50% max-len-diff] 1904123900.237 +- 0.0140.409 +- 0.022
SonicParanoid CORE (fast) [50% max-len-diff] 1645113010.232 +- 0.0150.404 +- 0.024
metaPhOrs 2347176120.256 +- 0.0130.427 +- 0.020
orthoinspector 1.30 (blast threshold 10-9) 2208155640.240 +- 0.0130.411 +- 0.021
phylomeDB 2380166260.244 +- 0.0130.417 +- 0.020
OMA Pairs (Refset5) 1314119970.212 +- 0.0160.364 +- 0.026




Project # completed tree samplings (of 50k trials) # uploaded orthologs avg RF distance( genetree , speciestree ) avg fraction incorrect trees Raw Data
EggNOG 221745720740.191 +- 0.0160.207 +- 0.017
Ensembl Compara (e56) 356250867960.224 +- 0.0150.246 +- 0.015
Ensembl Compara (e81) 380658745880.241 +- 0.0150.268 +- 0.016
Hieranoid 2 386263496660.211 +- 0.0140.231 +- 0.015
InParanoid 466184476460.200 +- 0.0140.228 +- 0.015
InParanoidCore 253033554200.176 +- 0.0140.195 +- 0.015
OMA GETHOGs 463980681110.191 +- 0.0140.219 +- 0.015
OMA GETHOGs 2.0 3751202969630.217 +- 0.0140.232 +- 0.015
OMA Groups (RefSet5) 139319230930.167 +- 0.0190.174 +- 0.020
OMA Groups 2.0 202324662740.187 +- 0.0170.196 +- 0.017
OMA Pairs 2.0 388166110630.215 +- 0.0140.230 +- 0.015
OrthoFinder 2.0 (Defaults, with BLAST) 442589074940.231 +- 0.0150.259 +- 0.016
OrthoFinder 2.0 (Defaults, with DIAMOND) 435675076570.233 +- 0.0150.254 +- 0.016
OrthoFinder 2.0 (MSA, with BLAST) 407186128160.231 +- 0.0150.255 +- 0.016
PANTHER 8.0 (LDO only) 335833332450.218 +- 0.0140.242 +- 0.015
PANTHER 8.0 (all) 4877108613380.270 +- 0.0150.305 +- 0.016
RBH / BBH 431543007080.209 +- 0.0140.239 +- 0.015
RSD 0.8 1e-5 Deluca 378638165810.200 +- 0.0140.225 +- 0.015
SonicParanoid (default) [50% max-len-diff] 451387952230.202 +- 0.0140.231 +- 0.015
SonicParanoid (fast) [50% max-len-diff] 340176391850.200 +- 0.0140.225 +- 0.015
SonicParanoid CORE (default) [50% max-len-diff] 375439582570.198 +- 0.0140.222 +- 0.015
SonicParanoid CORE (fast) [50% max-len-diff] 277335407050.183 +- 0.0140.204 +- 0.015
metaPhOrs 284864970490.231 +- 0.0150.259 +- 0.016
orthoinspector 1.30 (blast threshold 10-9) 397454913990.211 +- 0.0140.244 +- 0.015
phylomeDB 304755672080.205 +- 0.0140.225 +- 0.015
OMA Pairs (Refset5) 316347742750.211 +- 0.0140.222 +- 0.015



Project # completed tree samplings (of 50k trials) # uploaded orthologs avg RF distance( genetree , speciestree ) avg fraction incorrect trees Raw Data
EggNOG 418240947360.255 +- 0.0100.537 +- 0.018
Ensembl Compara (e56) 364940816600.252 +- 0.0100.529 +- 0.018
Ensembl Compara (e81) 411047429670.276 +- 0.0110.563 +- 0.018
Hieranoid 2 412255229630.237 +- 0.0100.515 +- 0.018
InParanoid 476368048730.240 +- 0.0100.509 +- 0.018
InParanoidCore 296528824870.231 +- 0.0100.487 +- 0.018
OMA GETHOGs 353465931800.2465 +- 0.00950.546 +- 0.018
OMA GETHOGs 2.0 2863181762000.2194 +- 0.00950.494 +- 0.018
OMA Groups (RefSet5) 75617080100.176 +- 0.0170.402 +- 0.035
OMA Groups 2.0 123621342530.197 +- 0.0140.444 +- 0.028
OMA Pairs 2.0 251358211050.224 +- 0.0100.496 +- 0.020
OrthoFinder 2.0 (Defaults, with BLAST) 629075432550.264 +- 0.0100.543 +- 0.018
OrthoFinder 2.0 (Defaults, with DIAMOND) 604963889260.256 +- 0.0100.543 +- 0.018
OrthoFinder 2.0 (MSA, with BLAST) 673273812380.278 +- 0.0100.589 +- 0.018
PANTHER 8.0 (LDO only) 476928158510.251 +- 0.0100.527 +- 0.018
PANTHER 8.0 (all) 672489056220.299 +- 0.0110.580 +- 0.018
RBH / BBH 526534342600.247 +- 0.0100.529 +- 0.018
RSD 0.8 1e-5 Deluca 444630884320.250 +- 0.0100.525 +- 0.018
SonicParanoid (default) [50% max-len-diff] 513470813120.252 +- 0.0100.544 +- 0.018
SonicParanoid (fast) [50% max-len-diff] 408263871290.238 +- 0.0100.511 +- 0.018
SonicParanoid CORE (default) [50% max-len-diff] 414332028070.248 +- 0.0100.519 +- 0.018
SonicParanoid CORE (fast) [50% max-len-diff] 344129735400.236 +- 0.0100.499 +- 0.018
metaPhOrs 354156761080.269 +- 0.0100.550 +- 0.018
orthoinspector 1.30 (blast threshold 10-9) 493145815770.255 +- 0.0100.547 +- 0.018
phylomeDB 337047299650.248 +- 0.0100.518 +- 0.018
OMA Pairs (Refset5) 227441547560.215 +- 0.0110.478 +- 0.021



Project # completed tree samplings (of 50k trials) # uploaded orthologs avg RF distance( genetree , speciestree ) avg fraction incorrect trees Raw Data
EggNOG 1439710971100.1977 +- 0.00690.678 +- 0.017
Ensembl Compara (e56) 1207111576750.1993 +- 0.00690.681 +- 0.017
Ensembl Compara (e81) 1346612466140.2091 +- 0.00730.694 +- 0.016
Hieranoid 2 1186812375080.1899 +- 0.00690.659 +- 0.017
InParanoid 1224214370550.2000 +- 0.00710.687 +- 0.017
InParanoidCore 89569476370.1649 +- 0.00620.623 +- 0.017
OMA GETHOGs 1154923684990.2057 +- 0.00710.689 +- 0.017
OMA GETHOGs 2.0 1121254029400.2061 +- 0.00770.666 +- 0.017
OMA Groups (RefSet5) 61458399880.1803 +- 0.00690.629 +- 0.017
OMA Groups 2.0 75709075480.1764 +- 0.00700.617 +- 0.017
OMA Pairs 2.0 1110424630850.1999 +- 0.00740.661 +- 0.017
OrthoFinder 2.0 (Defaults, with BLAST) 1848815998440.1984 +- 0.00680.691 +- 0.017
OrthoFinder 2.0 (Defaults, with DIAMOND) 1871714682960.2043 +- 0.00690.701 +- 0.016
OrthoFinder 2.0 (MSA, with BLAST) 2118617142440.2130 +- 0.00720.705 +- 0.016
PANTHER 8.0 (LDO only) 97409030110.1820 +- 0.00680.642 +- 0.017
PANTHER 8.0 (all) 1346417797710.2177 +- 0.00750.695 +- 0.016
RBH / BBH 1397210341290.1985 +- 0.00710.673 +- 0.017
RSD 0.8 1e-5 Deluca 1373010169750.1990 +- 0.00700.686 +- 0.017
SonicParanoid (default) [50% max-len-diff] 1433114501800.1953 +- 0.00690.676 +- 0.017
SonicParanoid (fast) [50% max-len-diff] 1418714458560.1964 +- 0.00700.676 +- 0.017
SonicParanoid CORE (default) [50% max-len-diff] 125369981340.1881 +- 0.00670.670 +- 0.017
SonicParanoid CORE (fast) [50% max-len-diff] 123619946750.1897 +- 0.00680.668 +- 0.017
metaPhOrs 1740215959180.2081 +- 0.00720.684 +- 0.017
orthoinspector 1.30 (blast threshold 10-9) 1524211752780.1966 +- 0.00690.674 +- 0.017
phylomeDB 1261813854180.1925 +- 0.00670.679 +- 0.017
OMA Pairs (Refset5) 1023917410900.2015 +- 0.00740.669 +- 0.017



Project # completed tree samplings (of 50k trials) # uploaded orthologs avg RF distance( genetree , speciestree ) avg fraction incorrect trees Raw Data
EggNOG 147821653690.079 +- 0.0100.079 +- 0.010
Ensembl Compara (e56) 148921788450.085 +- 0.0100.085 +- 0.010
Ensembl Compara (e81) 151221816050.094 +- 0.0100.094 +- 0.010
Hieranoid 2 152011756360.079 +- 0.0100.079 +- 0.010
InParanoid 164811898160.077 +- 0.0100.077 +- 0.010
InParanoidCore 135331454700.0607 +- 0.00850.0607 +- 0.0085
OMA GETHOGs 111301618830.0640 +- 0.00880.0640 +- 0.0088
OMA GETHOGs 2.0 89001461600.0597 +- 0.00850.0597 +- 0.0085
OMA Groups (RefSet5) 3584789520.0403 +- 0.00700.0403 +- 0.0070
OMA Groups 2.0 62911015790.0507 +- 0.00780.0507 +- 0.0078
OMA Pairs 2.0 99321474100.0627 +- 0.00870.0627 +- 0.0087
OrthoFinder 2.0 (Defaults, with BLAST) 202072300280.096 +- 0.0110.096 +- 0.011
OrthoFinder 2.0 (Defaults, with DIAMOND) 196512228220.092 +- 0.0100.092 +- 0.010
OrthoFinder 2.0 (MSA, with BLAST) 203142352010.097 +- 0.0110.097 +- 0.011
PANTHER 8.0 (LDO only) 156701406090.0753 +- 0.00940.0753 +- 0.0094
PANTHER 8.0 (all) 186272144650.108 +- 0.0110.108 +- 0.011
RBH / BBH 183041777500.095 +- 0.0100.095 +- 0.010
RSD 0.8 1e-5 Deluca 166081658510.0737 +- 0.00930.0737 +- 0.0093
SonicParanoid (default) [50% max-len-diff] 168451873810.077 +- 0.0100.077 +- 0.010
SonicParanoid (fast) [50% max-len-diff] 150681729250.0687 +- 0.00910.0687 +- 0.0091
SonicParanoid CORE (default) [50% max-len-diff] 156931598680.0723 +- 0.00930.0723 +- 0.0093
SonicParanoid CORE (fast) [50% max-len-diff] 139301473790.0680 +- 0.00900.0680 +- 0.0090
metaPhOrs 155811778110.081 +- 0.0100.081 +- 0.010
orthoinspector 1.30 (blast threshold 10-9) 168251834750.083 +- 0.0100.083 +- 0.010
phylomeDB 162991878760.0707 +- 0.00920.0707 +- 0.0092
OMA Pairs (Refset5) 87781355980.0637 +- 0.00870.0637 +- 0.0087



Case Project pos. predictive value rate true positive rate Raw Data
APPEggNOG 0.913 +- 0.1628560.2442 +- 0.128407
 Ensembl Compara (e56) 0.9767 +- 0.04504850.9767 +- 0.0450485
 Ensembl Compara (e81) 0.9459 +- 0.1030430.407 +- 0.146839
 Hieranoid 2 0.9452 +- 0.07383140.8023 +- 0.119034
 InParanoid 0.9683 +- 0.06122670.7093 +- 0.135725
 InParanoidCore 0.9487 +- 0.09790160.4302 +- 0.147987
 OMA GETHOGs 0.9701 +- 0.05762770.7558 +- 0.128407
 OMA GETHOGs 2.0 0.9655 +- 0.06641070.6512 +- 0.142455
 OMA Groups (RefSet5) 0.9167 +- 0.156380.2558 +- 0.130414
 OMA Groups 2.0 0.931 +- 0.1304280.314 +- 0.138717
 OMA Pairs 2.0 0.9649 +- 0.06755460.6395 +- 0.143511
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9767 +- 0.04504850.9767 +- 0.0450485
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9718 +- 0.0544280.8023 +- 0.119034
 OrthoFinder 2.0 (MSA, with BLAST) 0.9767 +- 0.04504850.9767 +- 0.0450485
 PANTHER 8.0 (LDO only) 0.9487 +- 0.09790160.4302 +- 0.147987
 PANTHER 8.0 (all) 0.9718 +- 0.0544280.8023 +- 0.119034
 RBH / BBH 0.9512 +- 0.09324860.4535 +- 0.148801
 RSD 0.8 1e-5 Deluca 0.931 +- 0.1304280.314 +- 0.138717
 SonicParanoid (default) [50% max-len-diff] 0.9756 +- 0.04721810.9302 +- 0.0761454
 SonicParanoid (fast) [50% max-len-diff] 0.9756 +- 0.04721810.9302 +- 0.0761454
 SonicParanoid CORE (default) [50% max-len-diff] 0.9565 +- 0.08334430.5116 +- 0.149408
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9565 +- 0.08334430.5116 +- 0.149408
 metaPhOrs 0.971 +- 0.05598230.7791 +- 0.124005
 orthoinspector 1.30 (blast threshold 10-9) 0.9688 +- 0.06028520.7209 +- 0.134068
 phylomeDB 0.9706 +- 0.0567930.7674 +- 0.126273
 OMA Pairs (Refset5) 0.96 +- 0.0768160.5581 +- 0.148435
ASTEREggNOG 0.9845 +- 0.03015090.386 +- 0.0743969
 Ensembl Compara (e56) 0.9835 +- 0.03212790.3617 +- 0.0734278
 Ensembl Compara (e81) 0.9845 +- 0.03015090.386 +- 0.0743969
 Hieranoid 2 0.9892 +- 0.02107430.5562 +- 0.0759241
 InParanoid 0.9886 +- 0.02227170.5258 +- 0.0763067
 InParanoidCore 0.9841 +- 0.0308630.3769 +- 0.0740569
 OMA GETHOGs 0.989 +- 0.02153770.5441 +- 0.0761114
 OMA GETHOGs 2.0 0.9845 +- 0.03015090.386 +- 0.0743969
 OMA Groups (RefSet5) 0.9825 +- 0.03408320.3404 +- 0.0724129
 OMA Groups 2.0 0.9825 +- 0.03408320.3404 +- 0.0724129
 OMA Pairs 2.0 0.9853 +- 0.02861060.4073 +- 0.0750839
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9895 +- 0.0205230.5714 +- 0.075625
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9851 +- 0.02903450.4012 +- 0.0749028
 OrthoFinder 2.0 (MSA, with BLAST) 0.9895 +- 0.0205230.5714 +- 0.075625
 PANTHER 8.0 (LDO only) 0.989 +- 0.02153770.5441 +- 0.0761114
 PANTHER 8.0 (all) 0.989 +- 0.02153770.5441 +- 0.0761114
 RBH / BBH 0.9898 +- 0.0197970.5927 +- 0.0750839
 RSD 0.8 1e-5 Deluca 0.9868 +- 0.0257880.4529 +- 0.0760687
 SonicParanoid (default) [50% max-len-diff] 0.9882 +- 0.02305730.5076 +- 0.0764
 SonicParanoid (fast) [50% max-len-diff] 0.9853 +- 0.02861060.4073 +- 0.0750839
 SonicParanoid CORE (default) [50% max-len-diff] 0.9872 +- 0.02496670.4681 +- 0.0762528
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9853 +- 0.02861060.4073 +- 0.0750839
 metaPhOrs 0.9864 +- 0.02648470.4407 +- 0.07587
 orthoinspector 1.30 (blast threshold 10-9) 0.9845 +- 0.03015090.386 +- 0.0743969
 phylomeDB 0.9877 +- 0.02390080.4894 +- 0.0763915
 OMA Pairs (Refset5) 0.9853 +- 0.02861060.4073 +- 0.0750839
BAMBIEggNOG 0.9759 +- 0.04665620.757 +- 0.114928
 Ensembl Compara (e56) 0.963 +- 0.05816350.729 +- 0.119108
 Ensembl Compara (e81) 0.9571 +- 0.06709990.6262 +- 0.129647
 Hieranoid 2 0.9714 +- 0.05519410.6355 +- 0.128968
 InParanoid 0.9714 +- 0.05519410.6355 +- 0.128968
 InParanoidCore 0.9661 +- 0.06530480.5327 +- 0.133696
 OMA GETHOGs 0.975 +- 0.04838380.729 +- 0.119108
 OMA GETHOGs 2.0 0.9714 +- 0.05519410.6355 +- 0.128968
 OMA Groups (RefSet5) 0.9714 +- 0.05519410.6355 +- 0.128968
 OMA Groups 2.0 0.9714 +- 0.05519410.6355 +- 0.128968
 OMA Pairs 2.0 0.974 +- 0.05024370.7009 +- 0.122688
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9722 +- 0.04383180.9813 +- 0.0362918
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9634 +- 0.05746780.7383 +- 0.117784
 OrthoFinder 2.0 (MSA, with BLAST) 0.9789 +- 0.04082640.8692 +- 0.0903651
 PANTHER 8.0 (LDO only) 0.9756 +- 0.04721810.7477 +- 0.116392
 PANTHER 8.0 (all) 0.9681 +- 0.05025290.8505 +- 0.09556
 RBH / BBH 0.9783 +- 0.04214320.8411 +- 0.0979582
 RSD 0.8 1e-5 Deluca 0.9747 +- 0.04898820.7196 +- 0.120365
 SonicParanoid (default) [50% max-len-diff] 0.9762 +- 0.04610790.7664 +- 0.113389
 SonicParanoid (fast) [50% max-len-diff] 0.9762 +- 0.04610790.7664 +- 0.113389
 SonicParanoid CORE (default) [50% max-len-diff] 0.9759 +- 0.04665620.757 +- 0.114928
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9759 +- 0.04665620.757 +- 0.114928
 metaPhOrs 0.9744 +- 0.04960780.7103 +- 0.121558
 orthoinspector 1.30 (blast threshold 10-9) 0.9756 +- 0.04721810.7477 +- 0.116392
 phylomeDB 0.9759 +- 0.04665620.757 +- 0.114928
 OMA Pairs (Refset5) 0.974 +- 0.05024370.7009 +- 0.122688
BAREggNOG 0.9878 +- 0.02375650.4894 +- 0.0761606
 Ensembl Compara (e56) 0.9923 +- 0.01496150.7825 +- 0.0628558
 Ensembl Compara (e81) 0.9911 +- 0.01734460.6737 +- 0.071432
 Hieranoid 2 0.9916 +- 0.01647020.71 +- 0.0691352
 InParanoid 0.8178 +- 0.06523060.6647 +- 0.0719285
 InParanoidCore 0.947 +- 0.05406470.3776 +- 0.0738613
 OMA GETHOGs 0.9533 +- 0.03647920.7402 +- 0.066813
 OMA GETHOGs 2.0 0.9358 +- 0.04967280.5287 +- 0.076052
 OMA Groups (RefSet5) 0.9688 +- 0.04262810.3746 +- 0.0737437
 OMA Groups 2.0 0.9701 +- 0.04074870.3927 +- 0.0744044
 OMA Pairs 2.0 0.94 +- 0.04654740.568 +- 0.0754702
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9928 +- 0.01404990.8338 +- 0.0567108
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9928 +- 0.01399970.8369 +- 0.0562943
 OrthoFinder 2.0 (MSA, with BLAST) 0.9928 +- 0.01404990.8338 +- 0.0567108
 PANTHER 8.0 (LDO only) 0.99 +- 0.01950180.5982 +- 0.0746943
 PANTHER 8.0 (all) 0.5772 +- 0.0688970.6888 +- 0.0705366
 RBH / BBH 0.7792 +- 0.07421860.565 +- 0.075532
 RSD 0.8 1e-5 Deluca 0.8313 +- 0.0665930.6103 +- 0.0743018
 SonicParanoid (default) [50% max-len-diff] 0.9479 +- 0.04444840.5498 +- 0.075798
 SonicParanoid (fast) [50% max-len-diff] 0.9832 +- 0.03266330.3535 +- 0.0728332
 SonicParanoid CORE (default) [50% max-len-diff] 0.9721 +- 0.03413890.5257 +- 0.076077
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9823 +- 0.03438170.3353 +- 0.0719285
 metaPhOrs 0.9829 +- 0.02097290.8701 +- 0.0512224
 orthoinspector 1.30 (blast threshold 10-9) 0.83 +- 0.06545370.6344 +- 0.0733721
 phylomeDB 0.9921 +- 0.01549370.7553 +- 0.0655001
 OMA Pairs (Refset5) 0.9388 +- 0.04746640.5559 +- 0.0757002
CASPEggNOG 0.5 +- 0.6929650.5 +- 0.692965
 Ensembl Compara (e56) 0.5 +- 0.6929650.5 +- 0.692965
 Ensembl Compara (e81) 0.5 +- 0.6929650.5 +- 0.692965
 Hieranoid 2 0.5 +- 0.6929650.5 +- 0.692965
 InParanoid 0.5 +- 0.6929650.5 +- 0.692965
 InParanoidCore 0.5 +- 0.6929650.5 +- 0.692965
 OMA GETHOGs 0.5 +- 0.6929650.5 +- 0.692965
 OMA GETHOGs 2.0 0.5 +- 0.6929650.5 +- 0.692965
 OMA Groups (RefSet5) 0.5 +- 0.6929650.5 +- 0.692965
 OMA Groups 2.0 0.5 +- 0.6929650.5 +- 0.692965
 OMA Pairs 2.0 0.5 +- 0.6929650.5 +- 0.692965
 OrthoFinder 2.0 (Defaults, with BLAST) 0.5 +- 0.6929650.5 +- 0.692965
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.5 +- 0.6929650.5 +- 0.692965
 OrthoFinder 2.0 (MSA, with BLAST) 0.5 +- 0.6929650.5 +- 0.692965
 PANTHER 8.0 (LDO only) 0.5 +- 0.6929650.5 +- 0.692965
 PANTHER 8.0 (all) 0.5 +- 0.6929650.5 +- 0.692965
 RBH / BBH 0.5 +- 0.6929650.5 +- 0.692965
 RSD 0.8 1e-5 Deluca 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid (default) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid (fast) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid CORE (default) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid CORE (fast) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 metaPhOrs 0.5 +- 0.6929650.5 +- 0.692965
 orthoinspector 1.30 (blast threshold 10-9) 0.5 +- 0.6929650.5 +- 0.692965
 phylomeDB 0.5 +- 0.6929650.5 +- 0.692965
 OMA Pairs (Refset5) 0.5 +- 0.6929650.5 +- 0.692965
CITEEggNOG 0.931 +- 0.1304280.4154 +- 0.169424
 Ensembl Compara (e56) 0.8 +- 0.1495030.6769 +- 0.160782
 Ensembl Compara (e81) 0.6053 +- 0.2197890.3538 +- 0.164395
 Hieranoid 2 0.9394 +- 0.1151320.4769 +- 0.17172
 InParanoid 0.9412 +- 0.1118520.4923 +- 0.171883
 InParanoidCore 0.9167 +- 0.156380.3385 +- 0.162685
 OMA GETHOGs 0.9412 +- 0.1118520.4923 +- 0.171883
 OMA GETHOGs 2.0 0.92 +- 0.1503970.3538 +- 0.164395
 OMA Groups (RefSet5) 0.9167 +- 0.156380.3385 +- 0.162685
 OMA Groups 2.0 0.9167 +- 0.156380.3385 +- 0.162685
 OMA Pairs 2.0 0.9231 +- 0.1448540.3692 +- 0.16592
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9692 +- 0.05937250.9692 +- 0.0593725
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9592 +- 0.07835020.7231 +- 0.153846
 OrthoFinder 2.0 (MSA, with BLAST) 0.9153 +- 0.1005020.8308 +- 0.128912
 PANTHER 8.0 (LDO only) 0.9429 +- 0.1087530.5077 +- 0.171883
 PANTHER 8.0 (all) 0.9592 +- 0.07835020.7231 +- 0.153846
 RBH / BBH 0.9412 +- 0.1118520.4923 +- 0.171883
 RSD 0.8 1e-5 Deluca 0.9333 +- 0.1262360.4308 +- 0.170248
 SonicParanoid (default) [50% max-len-diff] 0.9459 +- 0.1030430.5385 +- 0.171394
 SonicParanoid (fast) [50% max-len-diff] 0.9459 +- 0.1030430.5385 +- 0.171394
 SonicParanoid CORE (default) [50% max-len-diff] 0.931 +- 0.1304280.4154 +- 0.169424
 SonicParanoid CORE (fast) [50% max-len-diff] 0.931 +- 0.1304280.4154 +- 0.169424
 metaPhOrs 0.9565 +- 0.08334430.6769 +- 0.160782
 orthoinspector 1.30 (blast threshold 10-9) 0.92 +- 0.1503970.3538 +- 0.164395
 phylomeDB 0.92 +- 0.1503970.3538 +- 0.164395
 OMA Pairs (Refset5) 0.9231 +- 0.1448540.3692 +- 0.16592
ClusterinEggNOG 0.8462 +- 0.2773750.8462 +- 0.277375
 Ensembl Compara (e56) 0.8462 +- 0.2773750.8462 +- 0.277375
 Ensembl Compara (e81) 0.8462 +- 0.2773750.8462 +- 0.277375
 Hieranoid 2 0.8462 +- 0.2773750.8462 +- 0.277375
 InParanoid 0.8462 +- 0.2773750.8462 +- 0.277375
 InParanoidCore 0.8462 +- 0.2773750.8462 +- 0.277375
 OMA GETHOGs 0.8462 +- 0.2773750.8462 +- 0.277375
 OMA GETHOGs 2.0 0.8462 +- 0.2773750.8462 +- 0.277375
 OMA Groups (RefSet5) 0.8462 +- 0.2773750.8462 +- 0.277375
 OMA Groups 2.0 0.8462 +- 0.2773750.8462 +- 0.277375
 OMA Pairs 2.0 0.8462 +- 0.2773750.8462 +- 0.277375
 OrthoFinder 2.0 (Defaults, with BLAST) 0.8462 +- 0.2773750.8462 +- 0.277375
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.8462 +- 0.2773750.8462 +- 0.277375
 OrthoFinder 2.0 (MSA, with BLAST) 0.8462 +- 0.2773750.8462 +- 0.277375
 PANTHER 8.0 (LDO only) 0.8462 +- 0.2773750.8462 +- 0.277375
 PANTHER 8.0 (all) 0.8462 +- 0.2773750.8462 +- 0.277375
 RBH / BBH 0.8462 +- 0.2773750.8462 +- 0.277375
 RSD 0.8 1e-5 Deluca 0.8462 +- 0.2773750.8462 +- 0.277375
 SonicParanoid (default) [50% max-len-diff] 0.8462 +- 0.2773750.8462 +- 0.277375
 SonicParanoid (fast) [50% max-len-diff] 0.8333 +- 0.2982050.7692 +- 0.323904
 SonicParanoid CORE (default) [50% max-len-diff] 0.8462 +- 0.2773750.8462 +- 0.277375
 SonicParanoid CORE (fast) [50% max-len-diff] 0.8333 +- 0.2982050.7692 +- 0.323904
 metaPhOrs 0.8462 +- 0.2773750.8462 +- 0.277375
 orthoinspector 1.30 (blast threshold 10-9) 0.8462 +- 0.2773750.8462 +- 0.277375
 phylomeDB 0.8182 +- 0.3223430.6923 +- 0.354819
 OMA Pairs (Refset5) 0.8462 +- 0.2773750.8462 +- 0.277375
GH14EggNOG 0.5 +- 0.6929650.5 +- 0.692965
 Ensembl Compara (e56) 0.5 +- 0.6929650.5 +- 0.692965
 Ensembl Compara (e81) 0.5 +- 0.6929650.5 +- 0.692965
 Hieranoid 2 0.5 +- 0.6929650.5 +- 0.692965
 InParanoid 0.5 +- 0.6929650.5 +- 0.692965
 InParanoidCore 0.5 +- 0.6929650.5 +- 0.692965
 OMA GETHOGs 0.5 +- 0.6929650.5 +- 0.692965
 OMA GETHOGs 2.0 0.5 +- 0.6929650.5 +- 0.692965
 OMA Groups (RefSet5) 0.5 +- 0.6929650.5 +- 0.692965
 OMA Groups 2.0 0.5 +- 0.6929650.5 +- 0.692965
 OMA Pairs 2.0 0.5 +- 0.6929650.5 +- 0.692965
 OrthoFinder 2.0 (Defaults, with BLAST) 0.5 +- 0.6929650.5 +- 0.692965
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.5 +- 0.6929650.5 +- 0.692965
 OrthoFinder 2.0 (MSA, with BLAST) 0.5 +- 0.6929650.5 +- 0.692965
 PANTHER 8.0 (LDO only) 0.5 +- 0.6929650.5 +- 0.692965
 PANTHER 8.0 (all) 0.5 +- 0.6929650.5 +- 0.692965
 RBH / BBH 0.5 +- 0.6929650.5 +- 0.692965
 RSD 0.8 1e-5 Deluca 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid (default) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid (fast) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid CORE (default) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 SonicParanoid CORE (fast) [50% max-len-diff] 0.5 +- 0.6929650.5 +- 0.692965
 metaPhOrs 0.5 +- 0.6929650.5 +- 0.692965
 orthoinspector 1.30 (blast threshold 10-9) 0.5 +- 0.6929650.5 +- 0.692965
 phylomeDB 0.5 +- 0.6929650.5 +- 0.692965
 OMA Pairs (Refset5) 0.5 +- 0.6929650.5 +- 0.692965
HOXEggNOG 0.9124 +- 0.06694770.448 +- 0.0825239
 Ensembl Compara (e56) 0.1975 +- 0.08670510.1147 +- 0.0528797
 Ensembl Compara (e81) 0.5455 +- 0.1154170.2796 +- 0.0744748
 Hieranoid 2 0.86 +- 0.09617990.3082 +- 0.076629
 InParanoid 0.9138 +- 0.07223310.3799 +- 0.0805455
 InParanoidCore 0.9359 +- 0.07687320.2616 +- 0.0729391
 OMA GETHOGs 0.5854 +- 0.1066340.3441 +- 0.0788364
 OMA GETHOGs 2.0 0.8091 +- 0.1038690.319 +- 0.0773458
 OMA Groups (RefSet5) 0.918 +- 0.09735440.2007 +- 0.0664677
 OMA Groups 2.0 0.9091 +- 0.09808580.2151 +- 0.068181
 OMA Pairs 2.0 0.8037 +- 0.1064280.3082 +- 0.076629
 OrthoFinder 2.0 (Defaults, with BLAST) 0.7702 +- 0.07606870.6487 +- 0.0792167
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.7545 +- 0.08042450.595 +- 0.0814625
 OrthoFinder 2.0 (MSA, with BLAST) 0.8851 +- 0.06702280.552 +- 0.0825239
 PANTHER 8.0 (LDO only) 0.9344 +- 0.08785040.2043 +- 0.0669081
 PANTHER 8.0 (all) 0.4529 +- 0.07482890.552 +- 0.0825239
 RBH / BBH 0.9381 +- 0.06285740.3799 +- 0.0805455
 RSD 0.8 1e-5 Deluca 0.9368 +- 0.06917610.319 +- 0.0773458
 SonicParanoid (default) [50% max-len-diff] 0.9202 +- 0.05881760.5376 +- 0.082738
 SonicParanoid (fast) [50% max-len-diff] 0.9202 +- 0.05881760.5376 +- 0.082738
 SonicParanoid CORE (default) [50% max-len-diff] 0.9541 +- 0.05554340.3728 +- 0.0802418
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9541 +- 0.05554340.3728 +- 0.0802418
 metaPhOrs 0.8905 +- 0.06104010.6416 +- 0.0795777
 orthoinspector 1.30 (blast threshold 10-9) 0.8246 +- 0.08062080.5054 +- 0.0829687
 phylomeDB 0.9109 +- 0.07857860.3297 +- 0.0780151
 OMA Pairs (Refset5) 0.8333 +- 0.1022830.3047 +- 0.0763792
MAPTEggNOG 0.7778 +- 0.3841240.7778 +- 0.384124
 Ensembl Compara (e56) 0.7778 +- 0.3841240.7778 +- 0.384124
 Ensembl Compara (e81) 0.7778 +- 0.3841240.7778 +- 0.384124
 Hieranoid 2 0.7778 +- 0.3841240.7778 +- 0.384124
 InParanoid 0.7778 +- 0.3841240.7778 +- 0.384124
 InParanoidCore 0.7778 +- 0.3841240.7778 +- 0.384124
 OMA GETHOGs 0.7778 +- 0.3841240.7778 +- 0.384124
 OMA GETHOGs 2.0 0.7778 +- 0.3841240.7778 +- 0.384124
 OMA Groups (RefSet5) 0.75 +- 0.4243520.6667 +- 0.435556
 OMA Groups 2.0 0.75 +- 0.4243520.6667 +- 0.435556
 OMA Pairs 2.0 0.7778 +- 0.3841240.7778 +- 0.384124
 OrthoFinder 2.0 (Defaults, with BLAST) 0.7778 +- 0.3841240.7778 +- 0.384124
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.7778 +- 0.3841240.7778 +- 0.384124
 OrthoFinder 2.0 (MSA, with BLAST) 0.7778 +- 0.3841240.7778 +- 0.384124
 PANTHER 8.0 (LDO only) 0.7778 +- 0.3841240.7778 +- 0.384124
 PANTHER 8.0 (all) 0.7778 +- 0.3841240.7778 +- 0.384124
 RBH / BBH 0.7778 +- 0.3841240.7778 +- 0.384124
 RSD 0.8 1e-5 Deluca 0.7778 +- 0.3841240.7778 +- 0.384124
 SonicParanoid (default) [50% max-len-diff] 0.7778 +- 0.3841240.7778 +- 0.384124
 SonicParanoid (fast) [50% max-len-diff] 0.7778 +- 0.3841240.7778 +- 0.384124
 SonicParanoid CORE (default) [50% max-len-diff] 0.7778 +- 0.3841240.7778 +- 0.384124
 SonicParanoid CORE (fast) [50% max-len-diff] 0.7778 +- 0.3841240.7778 +- 0.384124
 metaPhOrs 0.7778 +- 0.3841240.7778 +- 0.384124
 orthoinspector 1.30 (blast threshold 10-9) 0.7778 +- 0.3841240.7778 +- 0.384124
 phylomeDB 0.75 +- 0.4243520.6667 +- 0.435556
 OMA Pairs (Refset5) 0.7778 +- 0.3841240.7778 +- 0.384124
NOXEggNOG 0.995 +- 0.009678910.704 +- 0.0529508
 Ensembl Compara (e56) 0.875 +- 0.0582110.38 +- 0.0563052
 Ensembl Compara (e81) 0.8711 +- 0.04972530.5324 +- 0.0578774
 Hieranoid 2 0.8692 +- 0.04010250.8266 +- 0.0439141
 InParanoid 0.9387 +- 0.03291170.6708 +- 0.0545123
 InParanoidCore 0.9921 +- 0.01549370.4378 +- 0.0575493
 OMA GETHOGs 0.8662 +- 0.03858610.9072 +- 0.0336607
 OMA GETHOGs 2.0 0.9954 +- 0.009011520.7566 +- 0.0497813
 OMA Groups (RefSet5) 0.9919 +- 0.0158060.4291 +- 0.0574129
 OMA Groups 2.0 0.9933 +- 0.01306650.5201 +- 0.0579524
 OMA Pairs 2.0 0.9544 +- 0.02691840.7706 +- 0.0487729
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9643 +- 0.02357710.8039 +- 0.0460608
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9192 +- 0.03035850.9965 +- 0.006853
 OrthoFinder 2.0 (MSA, with BLAST) 0.9714 +- 0.01954850.951 +- 0.0250497
 PANTHER 8.0 (LDO only) 0.8992 +- 0.05194850.4063 +- 0.056972
 PANTHER 8.0 (all) 0.8173 +- 0.04250350.9089 +- 0.0333736
 RBH / BBH 0.9895 +- 0.01675670.4939 +- 0.0579951
 RSD 0.8 1e-5 Deluca 0.9897 +- 0.01646940.5026 +- 0.0579985
 SonicParanoid (default) [50% max-len-diff] 0.9353 +- 0.03340290.683 +- 0.0539744
 SonicParanoid (fast) [50% max-len-diff] 0.9353 +- 0.03340290.683 +- 0.0539744
 SonicParanoid CORE (default) [50% max-len-diff] 0.9927 +- 0.01425420.4764 +- 0.0579345
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9927 +- 0.01425420.4764 +- 0.0579345
 metaPhOrs 0.9964 +- 0.007088590.9632 +- 0.0218327
 orthoinspector 1.30 (blast threshold 10-9) 0.9427 +- 0.0291230.8074 +- 0.045747
 phylomeDB 0.9962 +- 0.00749530.9107 +- 0.0330828
 OMA Pairs (Refset5) 0.9669 +- 0.02410960.7163 +- 0.052292
POPEggNOG 0.986 +- 0.027220.6845 +- 0.0897505
 Ensembl Compara (e56) 0.9885 +- 0.02239890.835 +- 0.0716926
 Ensembl Compara (e81) 0.841 +- 0.07258090.7961 +- 0.0778066
 Hieranoid 2 0.9891 +- 0.0211880.8835 +- 0.0619599
 InParanoid 0.9701 +- 0.03327150.9466 +- 0.0434192
 InParanoidCore 0.9684 +- 0.0351660.8932 +- 0.0596472
 OMA GETHOGs 0.989 +- 0.02141970.8738 +- 0.0641348
 OMA GETHOGs 2.0 0.9883 +- 0.02278920.8204 +- 0.0741336
 OMA Groups (RefSet5) 0.9858 +- 0.02760330.6748 +- 0.0904722
 OMA Groups 2.0 0.9877 +- 0.02404740.7767 +- 0.0804283
 OMA Pairs 2.0 0.9882 +- 0.02292280.8155 +- 0.0749061
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9894 +- 0.02073990.9029 +- 0.0571796
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.8889 +- 0.06190720.8544 +- 0.0681221
 OrthoFinder 2.0 (MSA, with BLAST) 0.9903 +- 0.01893650.9903 +- 0.0189365
 PANTHER 8.0 (LDO only) 0.9897 +- 0.01999970.9369 +- 0.0469591
 PANTHER 8.0 (all) 0.9903 +- 0.01893650.9903 +- 0.0189365
 RBH / BBH 0.9837 +- 0.02587870.8786 +- 0.0630636
 RSD 0.8 1e-5 Deluca 0.9838 +- 0.02574030.8835 +- 0.0619599
 SonicParanoid (default) [50% max-len-diff] 0.9757 +- 0.02972030.9757 +- 0.0297203
 SonicParanoid (fast) [50% max-len-diff] 0.9757 +- 0.02972030.9757 +- 0.0297203
 SonicParanoid CORE (default) [50% max-len-diff] 0.98 +- 0.027440.9515 +- 0.0415048
 SonicParanoid CORE (fast) [50% max-len-diff] 0.98 +- 0.027440.9515 +- 0.0415048
 metaPhOrs 0.9848 +- 0.02406330.9466 +- 0.0434192
 orthoinspector 1.30 (blast threshold 10-9) 0.9614 +- 0.03713510.966 +- 0.0349903
 phylomeDB 0.9882 +- 0.02292280.8155 +- 0.0749061
 OMA Pairs (Refset5) 0.9878 +- 0.02375650.7864 +- 0.0791505
PSENEggNOG 0.9897 +- 0.01999970.9847 +- 0.0243064
 Ensembl Compara (e56) 0.9873 +- 0.02465240.7959 +- 0.0797956
 Ensembl Compara (e81) 0.9897 +- 0.01999970.9847 +- 0.0243064
 Hieranoid 2 0.9886 +- 0.02214540.8878 +- 0.0624991
 InParanoid 0.9867 +- 0.02595870.7551 +- 0.085141
 InParanoidCore 0.9796 +- 0.03958960.4898 +- 0.0989744
 OMA GETHOGs 0.9886 +- 0.02214540.8878 +- 0.0624991
 OMA GETHOGs 2.0 0.9886 +- 0.02214540.8878 +- 0.0624991
 OMA Groups (RefSet5) 0.9474 +- 0.1004070.1837 +- 0.0766651
 OMA Groups 2.0 0.971 +- 0.05598230.3418 +- 0.0939116
 OMA Pairs 2.0 0.9855 +- 0.02819950.6939 +- 0.0912497
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9898 +- 0.01989760.9898 +- 0.0198976
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9898 +- 0.01989760.9898 +- 0.0198976
 OrthoFinder 2.0 (MSA, with BLAST) 0.9898 +- 0.01989760.9898 +- 0.0198976
 PANTHER 8.0 (LDO only) 0.975 +- 0.04838380.398 +- 0.0969114
 PANTHER 8.0 (all) 0.9886 +- 0.02214540.8878 +- 0.0624991
 RBH / BBH 0.982 +- 0.03499570.5561 +- 0.0983694
 RSD 0.8 1e-5 Deluca 0.9817 +- 0.03563160.5459 +- 0.0985767
 SonicParanoid (default) [50% max-len-diff] 0.9889 +- 0.02165690.9082 +- 0.0571786
 SonicParanoid (fast) [50% max-len-diff] 0.9889 +- 0.02165690.9082 +- 0.0571786
 SonicParanoid CORE (default) [50% max-len-diff] 0.9823 +- 0.03438170.5663 +- 0.0981201
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9823 +- 0.03438170.5663 +- 0.0981201
 metaPhOrs 0.9878 +- 0.02375650.8265 +- 0.0749694
 orthoinspector 1.30 (blast threshold 10-9) 0.9889 +- 0.02165690.9082 +- 0.0571786
 phylomeDB 0.9877 +- 0.02390080.8214 +- 0.0758287
 OMA Pairs (Refset5) 0.9826 +- 0.03378940.5765 +- 0.0978285
RPSEggNOG 0.92 +- 0.1503970.5 +- 0.204344
 Ensembl Compara (e56) 0.92 +- 0.1503970.5 +- 0.204344
 Ensembl Compara (e81) 0.92 +- 0.1503970.5 +- 0.204344
 Hieranoid 2 0.9091 +- 0.169890.4348 +- 0.202598
 InParanoid 0.9444 +- 0.1058210.7391 +- 0.179459
 InParanoidCore 0.8462 +- 0.2773750.2391 +- 0.174327
 OMA GETHOGs 0.9565 +- 0.08334430.9565 +- 0.0833443
 OMA GETHOGs 2.0 0.92 +- 0.1503970.5 +- 0.204344
 OMA Groups (RefSet5) 0.8824 +- 0.21660.3261 +- 0.191585
 OMA Groups 2.0 0.8824 +- 0.21660.3261 +- 0.191585
 OMA Pairs 2.0 0.9355 +- 0.1223040.6304 +- 0.197269
 OrthoFinder 2.0 (Defaults, with BLAST) 0.92 +- 0.1503970.5 +- 0.204344
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.92 +- 0.1503970.5 +- 0.204344
 OrthoFinder 2.0 (MSA, with BLAST) 0.92 +- 0.1503970.5 +- 0.204344
 PANTHER 8.0 (LDO only) 0.9048 +- 0.1775550.413 +- 0.20123
 PANTHER 8.0 (all) 0.9565 +- 0.08334430.9565 +- 0.0833443
 RBH / BBH 0.9394 +- 0.1151320.6739 +- 0.191585
 RSD 0.8 1e-5 Deluca 0.9394 +- 0.1151320.6739 +- 0.191585
 SonicParanoid (default) [50% max-len-diff] 0.9375 +- 0.118610.6522 +- 0.19465
 SonicParanoid (fast) [50% max-len-diff] 0.9286 +- 0.1349070.5652 +- 0.202598
 SonicParanoid CORE (default) [50% max-len-diff] 0.9167 +- 0.156380.4783 +- 0.204151
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9 +- 0.1859420.3913 +- 0.199457
 metaPhOrs 0.9355 +- 0.1223040.6304 +- 0.197269
 orthoinspector 1.30 (blast threshold 10-9) 0.9259 +- 0.1397050.5435 +- 0.20357
 phylomeDB 0.92 +- 0.1503970.5 +- 0.204344
 OMA Pairs (Refset5) 0.9333 +- 0.1262360.6087 +- 0.199457
SERCEggNOG 0.9968 +- 0.006302250.571 +- 0.0416679
 Ensembl Compara (e56) 0.9801 +- 0.01458480.6365 +- 0.0404948
 Ensembl Compara (e81) 0.9746 +- 0.01446940.8155 +- 0.0326562
 Hieranoid 2 0.9964 +- 0.005829970.7555 +- 0.036182
 InParanoid 0.9974 +- 0.005045050.714 +- 0.0380432
 InParanoidCore 0.995 +- 0.009678910.3708 +- 0.0406661
 OMA GETHOGs 0.9461 +- 0.01908270.9391 +- 0.0201318
 OMA GETHOGs 2.0 0.9765 +- 0.01344520.8801 +- 0.027351
 OMA Groups (RefSet5) 0.9911 +- 0.01734460.2057 +- 0.0340313
 OMA Groups 2.0 0.9811 +- 0.02114890.2878 +- 0.0381163
 OMA Pairs 2.0 0.9832 +- 0.01234550.7555 +- 0.036182
 OrthoFinder 2.0 (Defaults, with BLAST) 0.998 +- 0.003892760.9262 +- 0.0220105
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.998 +- 0.003892760.9262 +- 0.0220105
 OrthoFinder 2.0 (MSA, with BLAST) 0.998 +- 0.00388120.929 +- 0.0216267
 PANTHER 8.0 (LDO only) 0.9941 +- 0.01146190.3127 +- 0.0390306
 PANTHER 8.0 (all) 0.9656 +- 0.01656760.8284 +- 0.0317411
 RBH / BBH 0.9941 +- 0.01156330.31 +- 0.0389355
 RSD 0.8 1e-5 Deluca 0.994 +- 0.01166650.3072 +- 0.0388392
 SonicParanoid (default) [50% max-len-diff] 0.9975 +- 0.004943240.7288 +- 0.0374293
 SonicParanoid (fast) [50% max-len-diff] 0.9974 +- 0.005130860.702 +- 0.0385054
 SonicParanoid CORE (default) [50% max-len-diff] 0.9941 +- 0.01152920.3109 +- 0.0389675
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9939 +- 0.0119510.2998 +- 0.0385737
 metaPhOrs 0.9978 +- 0.004265510.845 +- 0.0304671
 orthoinspector 1.30 (blast threshold 10-9) 0.9976 +- 0.004655570.774 +- 0.0352119
 phylomeDB 0.9977 +- 0.004480.8044 +- 0.0333926
 OMA Pairs (Refset5) 0.9887 +- 0.01105720.643 +- 0.0403365
SUMFEggNOG 0.95 +- 0.09551860.95 +- 0.0955186
 Ensembl Compara (e56) 0.95 +- 0.09551860.95 +- 0.0955186
 Ensembl Compara (e81) 0.95 +- 0.09551860.95 +- 0.0955186
 Hieranoid 2 0.95 +- 0.09551860.95 +- 0.0955186
 InParanoid 0.95 +- 0.09551860.95 +- 0.0955186
 InParanoidCore 0.9474 +- 0.1004070.9 +- 0.131481
 OMA GETHOGs 0.7451 +- 0.1691530.95 +- 0.0955186
 OMA GETHOGs 2.0 0.95 +- 0.09551860.95 +- 0.0955186
 OMA Groups (RefSet5) 0.9231 +- 0.1448540.6 +- 0.214707
 OMA Groups 2.0 0.9231 +- 0.1448540.6 +- 0.214707
 OMA Pairs 2.0 0.9487 +- 0.09790160.925 +- 0.115436
 OrthoFinder 2.0 (Defaults, with BLAST) 0.95 +- 0.09551860.95 +- 0.0955186
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.95 +- 0.09551860.95 +- 0.0955186
 OrthoFinder 2.0 (MSA, with BLAST) 0.95 +- 0.09551860.95 +- 0.0955186
 PANTHER 8.0 (LDO only) 0.7941 +- 0.1922130.675 +- 0.205274
 PANTHER 8.0 (all) 0.7451 +- 0.1691530.95 +- 0.0955186
 RBH / BBH 0.95 +- 0.09551860.95 +- 0.0955186
 RSD 0.8 1e-5 Deluca 0.9412 +- 0.1118520.8 +- 0.175308
 SonicParanoid (default) [50% max-len-diff] 0.95 +- 0.09551860.95 +- 0.0955186
 SonicParanoid (fast) [50% max-len-diff] 0.95 +- 0.09551860.95 +- 0.0955186
 SonicParanoid CORE (default) [50% max-len-diff] 0.95 +- 0.09551860.95 +- 0.0955186
 SonicParanoid CORE (fast) [50% max-len-diff] 0.95 +- 0.09551860.95 +- 0.0955186
 metaPhOrs 0.95 +- 0.09551860.95 +- 0.0955186
 orthoinspector 1.30 (blast threshold 10-9) 0.95 +- 0.09551860.95 +- 0.0955186
 phylomeDB 0.9412 +- 0.1118520.8 +- 0.175308
 OMA Pairs (Refset5) 0.9487 +- 0.09790160.925 +- 0.115436
TRFEEggNOG 0.9091 +- 0.169890.9091 +- 0.16989
 Ensembl Compara (e56) 0.8421 +- 0.2318790.7273 +- 0.263192
 Ensembl Compara (e81) 0.9048 +- 0.1775550.8636 +- 0.202803
 Hieranoid 2 0.9 +- 0.1859420.8182 +- 0.227931
 InParanoid 0.8947 +- 0.1951550.7727 +- 0.247655
 InParanoidCore 0.875 +- 0.2291770.6364 +- 0.28428
 OMA GETHOGs 0.9 +- 0.1859420.8182 +- 0.227931
 OMA GETHOGs 2.0 0.9 +- 0.1859420.8182 +- 0.227931
 OMA Groups (RefSet5) 0.8462 +- 0.2773750.5 +- 0.295481
 OMA Groups 2.0 0.8462 +- 0.2773750.5 +- 0.295481
 OMA Pairs 2.0 0.8947 +- 0.1951550.7727 +- 0.247655
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9091 +- 0.169890.9091 +- 0.16989
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9091 +- 0.169890.9091 +- 0.16989
 OrthoFinder 2.0 (MSA, with BLAST) 0.8 +- 0.2217490.9091 +- 0.16989
 PANTHER 8.0 (LDO only) 0.8947 +- 0.1951550.7727 +- 0.247655
 PANTHER 8.0 (all) 0.7826 +- 0.2383970.8182 +- 0.227931
 RBH / BBH 0.8824 +- 0.21660.6818 +- 0.275253
 RSD 0.8 1e-5 Deluca 0.875 +- 0.2291770.6364 +- 0.28428
 SonicParanoid (default) [50% max-len-diff] 0.8947 +- 0.1951550.7727 +- 0.247655
 SonicParanoid (fast) [50% max-len-diff] 0.8947 +- 0.1951550.7727 +- 0.247655
 SonicParanoid CORE (default) [50% max-len-diff] 0.8462 +- 0.2773750.5 +- 0.295481
 SonicParanoid CORE (fast) [50% max-len-diff] 0.8462 +- 0.2773750.5 +- 0.295481
 metaPhOrs 0.8947 +- 0.1951550.7727 +- 0.247655
 orthoinspector 1.30 (blast threshold 10-9) 0.9 +- 0.1859420.8182 +- 0.227931
 phylomeDB 0.9 +- 0.1859420.8182 +- 0.227931
 OMA Pairs (Refset5) 0.8947 +- 0.1951550.7727 +- 0.247655
VATBEggNOG 0.9959 +- 0.008082480.8654 +- 0.0400905
 Ensembl Compara (e56) 0.9867 +- 0.01498710.7971 +- 0.0472303
 Ensembl Compara (e81) 0.9957 +- 0.008430050.8294 +- 0.0441744
 Hieranoid 2 0.9685 +- 0.0229370.7738 +- 0.0491374
 InParanoid 0.9847 +- 0.01585520.8115 +- 0.045936
 InParanoidCore 0.9916 +- 0.01335430.6373 +- 0.056465
 OMA GETHOGs 0.9956 +- 0.008540290.8187 +- 0.0452514
 OMA GETHOGs 2.0 0.9954 +- 0.008949710.781 +- 0.0485752
 OMA Groups (RefSet5) 0.9922 +- 0.01519350.4578 +- 0.0585141
 OMA Groups 2.0 0.9922 +- 0.01519350.4578 +- 0.0585141
 OMA Pairs 2.0 0.9953 +- 0.009158890.763 +- 0.0499423
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9855 +- 0.01507320.8546 +- 0.0414033
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9855 +- 0.01507320.8546 +- 0.0414033
 OrthoFinder 2.0 (MSA, with BLAST) 0.9959 +- 0.007983720.8761 +- 0.038692
 PANTHER 8.0 (LDO only) 0.993 +- 0.01361090.5117 +- 0.0587078
 PANTHER 8.0 (all) 0.9956 +- 0.008540290.8187 +- 0.0452514
 RBH / BBH 0.9948 +- 0.0100770.693 +- 0.0541726
 RSD 0.8 1e-5 Deluca 0.9925 +- 0.01462650.4758 +- 0.0586548
 SonicParanoid (default) [50% max-len-diff] 0.9857 +- 0.01485930.8671 +- 0.0398637
 SonicParanoid (fast) [50% max-len-diff] 0.9857 +- 0.01485930.8671 +- 0.0398637
 SonicParanoid CORE (default) [50% max-len-diff] 0.9925 +- 0.01462650.4758 +- 0.0586548
 SonicParanoid CORE (fast) [50% max-len-diff] 0.9925 +- 0.01462650.4758 +- 0.0586548
 metaPhOrs 0.9947 +- 0.01045330.6679 +- 0.0553154
 orthoinspector 1.30 (blast threshold 10-9) 0.9858 +- 0.01479940.8707 +- 0.0394028
 phylomeDB 0.9954 +- 0.009073970.7702 +- 0.0494107
 OMA Pairs (Refset5) 0.9952 +- 0.009468440.7379 +- 0.0516519



Case Project pos. predictive value rate true positive rate Raw Data
TreeFamAEggNOG 0.9342 +- 0.003249640.5657 +- 0.00505699
 Ensembl Compara (e56) 0.9142 +- 0.004065150.4517 +- 0.00507746
 Ensembl Compara (e81) 0.9132 +- 0.00386150.5052 +- 0.00510097
 Hieranoid 2 0.9255 +- 0.00331750.6035 +- 0.00499069
 InParanoid 0.9285 +- 0.003186250.6317 +- 0.0049212
 InParanoidCore 0.9523 +- 0.003075080.4764 +- 0.00509555
 OMA GETHOGs 0.89 +- 0.003901730.5959 +- 0.00500656
 OMA GETHOGs 2.0 0.8355 +- 0.004427870.6096 +- 0.00497724
 OMA Groups (RefSet5) 0.9506 +- 0.003740670.3323 +- 0.00480592
 OMA Groups 2.0 0.946 +- 0.003593220.3895 +- 0.00497524
 OMA Pairs 2.0 0.903 +- 0.003774260.578 +- 0.00503876
 OrthoFinder 2.0 (Defaults, with BLAST) 0.9274 +- 0.003031290.7074 +- 0.00464168
 OrthoFinder 2.0 (Defaults, with DIAMOND) 0.9177 +- 0.003247630.6843 +- 0.00474207
 OrthoFinder 2.0 (MSA, with BLAST) 0.9305 +- 0.003006350.6928 +- 0.00470669
 PANTHER 8.0 (LDO only) 0.9494 +- 0.003289360.4388 +- 0.00506287
 PANTHER 8.0 (all) 0.8743 +- 0.003845350.6765 +- 0.00477283
 RBH / BBH 0.948 +- 0.0031420.4926 +- 0.00510071
 RSD 0.8 1e-5 Deluca 0.9489 +- 0.003255550.4515 +- 0.00507723
 SonicParanoid (default) [50% max-len-diff] 0.9274 +- 0.003179490.6426 +- 0.00488929
 SonicParanoid (fast) [50% max-len-diff] 0.9267 +- 0.003232990.6266 +- 0.00493504
 SonicParanoid CORE (default) [50% max-len-diff] 0.9479 +- 0.003228230.4678 +- 0.00509068
 SonicParanoid CORE (fast) [50% max-len-diff] 0.947 +- 0.00330020.4542 +- 0.0050798
 metaPhOrs 0.9484 +- 0.002648180.6894 +- 0.00472112
 orthoinspector 1.30 (blast threshold 10-9) 0.9268 +- 0.00316010.6551 +- 0.00484964
 phylomeDB 0.9491 +- 0.002768110.6232 +- 0.00494386
 OMA Pairs (Refset5) 0.9191 +- 0.003696090.5206 +- 0.0050969



Project # ortholog relations avg Schlicker Raw Data
EggNOG 736810.97185 +- 0.00082
Ensembl Compara (e56) 866050.9528 +- 0.0010
Ensembl Compara (e81) 976140.9471 +- 0.0010
Hieranoid 2 926360.95871 +- 0.00088
InParanoid 1131630.9295 +- 0.0011
InParanoidCore 769970.97461 +- 0.00077
OMA GETHOGs 1106830.9387 +- 0.0010
OMA GETHOGs 2.0 979890.9328 +- 0.0011
OMA Groups (RefSet5) 457460.98693 +- 0.00072
OMA Groups 2.0 574440.98353 +- 0.00074
OMA Pairs 2.0 867260.96585 +- 0.00085
OrthoFinder 2.0 (Defaults, with BLAST) 1006950.9490 +- 0.0010
OrthoFinder 2.0 (Defaults, with DIAMOND) 977510.95719 +- 0.00091
OrthoFinder 2.0 (MSA, with BLAST) 967600.95645 +- 0.00094
PANTHER 8.0 (LDO only) 684570.97329 +- 0.00086
PANTHER 8.0 (all) 1202040.9370 +- 0.0010
RBH / BBH 883790.9585 +- 0.0010
RSD 0.8 1e-5 Deluca 812800.96287 +- 0.00093
SonicParanoid (default) [50% max-len-diff] 1145210.9305 +- 0.0010
SonicParanoid (fast) [50% max-len-diff] 1035560.9381 +- 0.0010
SonicParanoid CORE (default) [50% max-len-diff] 839060.96064 +- 0.00094
SonicParanoid CORE (fast) [50% max-len-diff] 754330.96809 +- 0.00088
metaPhOrs 988290.9085 +- 0.0013
orthoinspector 1.30 (blast threshold 10-9) 1022510.95403 +- 0.00091
phylomeDB 893870.9524 +- 0.0010
OMA Pairs (Refset5) 791930.97378 +- 0.00079



Project # ortholog relations avg Schlicker Raw Data
EggNOG 779730.4991 +- 0.0016
Ensembl Compara (e56) 723870.4997 +- 0.0017
Ensembl Compara (e81) 908480.4940 +- 0.0015
Hieranoid 2 1041590.4933 +- 0.0014
InParanoid 1269030.4824 +- 0.0012
InParanoidCore 661630.5098 +- 0.0017
OMA GETHOGs 1231760.4815 +- 0.0012
OMA GETHOGs 2.0 1262620.4622 +- 0.0013
OMA Groups (RefSet5) 383410.5202 +- 0.0023
OMA Groups 2.0 477670.5156 +- 0.0021
OMA Pairs 2.0 889960.4910 +- 0.0015
OrthoFinder 2.0 (Defaults, with BLAST) 1249520.4838 +- 0.0013
OrthoFinder 2.0 (Defaults, with DIAMOND) 1176410.4835 +- 0.0013
OrthoFinder 2.0 (MSA, with BLAST) 1190190.4865 +- 0.0013
PANTHER 8.0 (LDO only) 615950.5118 +- 0.0018
PANTHER 8.0 (all) 1747520.4658 +- 0.0011
RBH / BBH 740240.5076 +- 0.0016
RSD 0.8 1e-5 Deluca 630700.5121 +- 0.0018
SonicParanoid (default) [50% max-len-diff] 1285910.4777 +- 0.0013
SonicParanoid (fast) [50% max-len-diff] 1172340.4802 +- 0.0013
SonicParanoid CORE (default) [50% max-len-diff] 663340.5090 +- 0.0017
SonicParanoid CORE (fast) [50% max-len-diff] 614910.5098 +- 0.0018
metaPhOrs 1352070.4756 +- 0.0012
orthoinspector 1.30 (blast threshold 10-9) 1033980.4957 +- 0.0014
phylomeDB 1043020.4900 +- 0.0014
OMA Pairs (Refset5) 756210.5005 +- 0.0016